Effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model

ZENG Ningbi; ZHAO Xi; ZENG Yi; HUANG Wenjing; YE Yanyan

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Effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model

更新时间：2023-05-22

- Effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model
- null Issue 7, Pages: 525(2019)
- 作者机构：
  
  陆军军医大学第一附属医院口腔科,重庆,400038
- 作者简介：
- 基金信息：
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  CLC：
- Published：2019，
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ZENG Ningbi, ZHAO Xi, ZENG Yi, et al. Effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model. [J]. null (7):525(2019)
DOI：

ZENG Ningbi, ZHAO Xi, ZENG Yi, et al. Effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model. [J]. null (7):525(2019) DOI：

摘要

目的探讨朱砂莲甲素对口腔鳞癌大鼠模型P63、TRPM8的影响。方法选取20只Wistar大鼠制作口腔鳞癌模型，成功16只，分为模型组和朱砂莲甲素组，每组8只；另外选择10只Wistar大鼠作为正常组。朱砂莲甲素组给予朱砂莲甲素进行治疗，其余2组大鼠采用无菌蒸馏水进行腹腔注射。3组大鼠进行平均体质量、肿瘤体积检查，病理形态学观察，采用Western blot检测P63、TRPM8、HGF、c-Met表达。结果模型组大鼠平均体质量低于正常组，肿瘤体积大于正常组，差异具有统计学意义（P＜0.05）；朱砂莲甲素组大鼠平均体质量高于模型组，肿瘤体积小于模型组，差异具有统计学意义（P＜0.05）。模型组大鼠P63、TRPM8、HGF、c-Met水平高于正常组，差异具有统计学意义（P＜0.05）；朱砂莲甲素组大鼠P63、TRPM8、HGF、cMet低于模型组，差异具有统计学意义（P＜0.05）。结论朱砂莲甲素可有效减小口腔鳞癌大鼠肿瘤体积，通过调节HGF/cMet信号通路改善P63、TRPM8水平，对临床治疗口腔鳞癌具有重要意义。

Abstract

Objective To study the effect of emodin on P63 and TRPM8 of oral squamous cell carcinoma in rat model. MethodsTwenty Wistar rats were selected to make oral squamous cell carcinoma models

16 of them were successfully divided into model group and emodin group

8 rats in each group.Another 10 Wistar rats were selected as the normal group.Emodin group was treated with emodin

the other two groups were injected with aseptic distilled water.The average body weight

tumor volume and pathomorphology of rats in 3 groups were examined

and the expressions of P63

TRPM8

HGF and cMet were detected by Western blot. Results The average body weight of the model group was lower than that of normal group

and the tumor volume of the model group was larger than that of normal group

the differences were statistically significant(P＜0.05).The average body weight of the emodin group was higher than that of model group

and the tumor volume of the emodin group was smaller than that of model group

the differences were statistically significant(P＜0.05).The levels of P63

TRPM8

HGF and cMet in model group were higher than those in normal group

the differences were statistically significant(P＜0.05).The levels of P63

TRPM8

HGF

cMet in emodin group were lower than those in model group

the differences were statistically significant(P＜0.05). Conclusion Emodin can effectively reduce the tumor volume of oral squamous cell carcinoma in rats

which regulates HGF/cMet signaling pathway to improve P63 and TRPM8 levels.It is important for clinical treatment of oral squamous cell carcinoma.

关键词

朱砂莲甲素口腔鳞癌肿瘤体积大鼠

Keywords

emodinoral squamous cell carcinomasgross tumor volumerat

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