OBJECTIVE：To investigate the effect of prostaglandin E1 combined with atorvastatin on related indicators in elderly patients with hypertensive nephropathy. METHODS：70 elderly patients with hypertensive nephropathy were randomly divided into control group and observation group. Control group was orally given 10 mg Atorvastatin calcium tablet，once a day；observation group was additionally given 10 μg Prostaglandin E1 injection，adding into 250 ml 0.9％ Sodium chloride injection by intravenous infusion，once a day. The treatment course for both groups was 2 weeks. All patients were given quality low-protein，low-salt and low cholesterol diet，depressurization，lipid-lowering and other conventional treatment. Heart rate（HR），systolic blood pressure （SBP），diastolic blood pressure（DBP），triglyceride（TG），total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C）， low-density lipoprotein cholesterol（LDL-C），serum creatinine（Scr），24h urinary protein（TP/24 h），microalbuminuria（mAlb），urinary β 2-microglobulin（β 2-MG），blood urea nitrogen（BUN）before and after treatment，and incidence of adverse reactions in 2 groups were observed. RESULTS：After treatment，HR，SBP，DBP，TG，TC and LDL-C in 2 groups were significantly lower than before，and difference was statistically significant（P＜0.05），but there was no significant difference in the above-mentioned indicators between 2 groups and HDL-C before and after treatment（P＞0.05）；Scr，TP/24 h，mAlb，β2-MG and BUN were significantly lower than before，and observation group was lower than control group，the differences were statistically significant（P＜ 0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS：Based on the conventional treatment，prostaglandin E1 combined with atorvastatin can effectively improve the HR，blood pressure and blood lipid of elderly patients with hypertensive nephropathy；however，prostaglandin E1 combined with atorvastatin is better than atorvastatin alone in aspect of protecting renal function，with similar safety.