OBJECTIVE：To provide reference for reducing and avoiding medication errors of high-alert drugs in outpatient department. METHODS：The medication errors of high-alert drugs in outpatient prescriptions were collected from our hospital during 2013-2014，and then analyzed retrospectively in terms of the type and degree of medication error，caused factors of medication errors， etc. RESULTS：670 997 prescriptions were checked in two years，and 501 medication errors were found，including 26 medication errors of high-alert medication. There were 7 incorrect route of administration of insulin，1 repeated medication and 1 incorrect dose of oral hypoglycemic agents，6 repeated administration of opioid drugs and non steroidal anti-inflammatory drugs，2 indication error of paracetamol and codeine phosphate，1 specification and 1 indication error of glucose injection，2 route of administration error of lidocaine，2 administration frequency errors of methotrexate，2 dose error of digoxin and 1 dose error of warfarin；18 doctors’prescribing errors were found by pharmacists’prescription audit，accounting for 69.2％ ；8 doctors’prescribing errors were not found by pharmacists’prescription audit，accounting for 30.8％. CONCLUSIONS：Medication errors of high-alert drugs occur mainly in the prescription segment，and the main reason is that the electronic prescription system lack of compulsory strategy and policy constraints. Improvement of safety administration of high-alert drugs need to find the error link and adopt targeted medication safety practices.