OBJECTIVE： To observe the therapeutic efficacy and safety of Danhong injection combined with pantoprazole in the treatment of acute exacerbation of respiratory failure. METHODS： 62 patients with acute exacerbation of respiratory failure were selected and randomly divided into observation group and control group， with 31 cases in each group. Both group received Oxygen， expectorant， tracheal intubation and ventilation， and electrolyte balance and acid-base balance. routine treatment. Control group was given Danhong injection 40 ml added into 0.9％ Sodium chloride solution 250 ml， ivgtt， qd； observation group was additionally given Pantoprazole injection 40 mg， q12 h. Both groups were treated for 15 d. Clinical efficacy of 2 groups were observed， and blood gas index， plasma viscosity and plasma lactate level were observed before and after treatment， and ADR was recorded. RESULTS： Total effective rate of observation group （90.32％） was significantly higher than that of control group （61.29％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in PaO2， SaO2， PaCO2， plasma viscosity and plasma lactate level between 2 groups （P＞0.05）； after treatment， PaO2， SaO2， PaCO2， plasma viscosity and plasma lactate level of two group was significantly better than those of before treatment. The observation group was signoticanely beteer than the control group， with statistical significance （P＜0.05）； no obvious ADR was found in 2 groups. CONCLUSIONS： Danhong injection combined with pantoprazole shows significant therapeutic efficacy and good safety in the treatment of acute exacerbation of respiratory failure.