OBJECTIVE： To investigate the situation of drug-induced liver injury caused by azole antifungal drug and discuss effective prevention and treatment measures， to provide reference for safe and rational use of azole antifungal drug in the clinic. METHODS： Drug-induced liver injury caused by azole antifungal drug were collected from published medical and pharmaceutical periodicals in China during Jan.1989-Dec. 2014， and then analyzed statistically in respects of patient’s age and gender， drug name， usage and dosage， onset time， outcome， etc. RESULTS： A total of 36 literatures were collected， involving 50 cases. Drug-induced liver injury were not related to patient’s age，  gender and treatment duration with cure rate of 88％. There were 29 cases of ketoconazole-induced liver injury （58％）， 9 cases of fluconazol-induced liver injury （18％）， 8 cases of itraconazole-induced liver injury （16％） and 4 cases of voriconazole-induced liver injury （8％）. There were 6 cases of poor outcome （12％）， of which 4 patients died due to treatment failure and 2 patients gave up treatment because of critical condition. 2 patients suffered from drug-induced liver injury caused by drug combination. CONCLUSIONS： Regular liver function detection and drug concentration monitoring should be provided for the patients when they use azole antifungal drug， and gene detection should be conducted when avalilable to reduce the risk of liver injury. The patients diagnosed as drug-induced liver injury should stop taking medicine immediately and receive supportive liver protection therapy as removing jaundice， enzyme reduction， artificial liver plasma exchange， liver transplantation and other surgery.