OBJECTIVE： To observe the clinical efficacy and safety of nicorandil combined with atorvastatin in the treatment of unstable angina pectoris. METHODS： 60 patients with unstable angina pectoris were selected and randomly divided into observation group and control group with 30 cases in each group. Control group was given isosorbide 5-mononitrate 40 mg， qd； observation group was given nicorandil 5 mg combined with atorvastatin 10 mg， tid. Both group were treated for consecutive one month. Clinical efficacy was observed in 2 groups and the incidence of electrocardiogram T wave inversion and ST segment elevation were also observed before and after treatment， and ADR was recorded. RESULTS： The effective rate of observation group was 93.33％， which was significantly higher than 16.67％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in the incidence of electrocardiogram T wave inversion and ST segment elevation between 2 groups （P＞0.05）； after treatment， the incidence of electrocardiogram T wave inversion and ST segment elevation in observation group was significantly lower than in control group， with statistical significance （P＜0.05）. The incidence of headache， rash， loss of appetite in observation group were significantly lower than in control group， with statistical significance （P＜0.05）， and there was no statistical significance in the incidence of diarrhea and facial blushing between 2 groups （P＞0.05）. CONCLUSIONS： Nicorandil combined with atorvastatin shows better therapeutic efficacy and good safety than isosorbide mononitrate in the treatment of unstable angina pectoris.