OBJECTIVE： To prepare Tadalafil oral films and to evaluate its quality. METHODS： Tadalafil oral films were prepared by solvent casting method with HPMC E5 as the film materials. The formability， thickness， disintegration time， folding strength and tensile strength were used as index to screen and optimize the type and amount of excipients. The in vitro dissolution behavior of the films was compared with that of commercial Tadalafil tablets. The stability （property， content & dissolution） of the films was studied at the temperature of （30±2） ℃ and the humidity of （65±5）％ for 6 months. RESULTS： The formulation of tadalafil was as follows as 0.45％ tadalafil， 2.5％ HPMC E5， 1.2％ PEG 400， 1.2％ glycerine， 0.3％ mannitol， 0.045％ menthene， added water to 100 g. Prepared Tadalafil oral films were ivory-white and semitransparent with thickness of （183.5±4.2）-（190.5±5.1） μm， disintegration time of 35-38 s， folding strength of 11-12， tensile strength of 4.273 1-4.410 5 kg/mm2 and content of 99.2％-99.5％. The in vitro dissolution of the films in 0.5％ SDS-Na medium was faster than that of commercial drug （cumulative dissolution of 10 min were 90.9％ vs. 72.3％）， and the films did not show any significant change in property， content or dissolution under accelerated temperature conditions for 6 months. CONCLUSIONS： Tadalafil oral films are reasonable， feasible in preparation process and stable， controllable in quality.