OBJECTIVE：To establish a method for the contents determination of rutin， liquiritin， psoralen， xanthotoxin， bergapten， ammonium glycyrrhetate， ophiopogonin D， methylophiopogonanone A and methylophiopogonanone B in Shasheng maidong decoction. METHODS： UPLC-MS/MS was conducted. The column of UPLC was Phenomenex Kenetix C18 with mobile phase of acetonitrile solution -0.1％ formic acid （gradient elution） at a flow rate of 0.3 ml/min， the column temperature was 25 ℃，injector temperature was 10 ℃， equilibrium time was 2 min and the injection volume was 5 μl. Ionization mode was electrospray ionization with spray voltage of 5 500 V and －4 500 V， atomizing air pressure was 4.14×105 Pa， heater pressure was 4.48×105 Pa， curtain air was 1.72×105 Pa， and the ion source temperature was 650 ℃，the work mode was multiple reaction monitoring mode. RESULTS：The linear range was 1.75-700 ng/ml （r＝0.999 2）for rutin，5.00-1 997 ng/ml （r＝0.999 7） for liquiritin， 0.95-380 ng/ml （r＝0.999 0） forpsoralen，1.75-700 ng/ml（r＝0.999 1） for xanthotoxin，2.00-800 ng/ml （r＝0.999 8） for bergapten，7.00-2 799 ng/ml （r＝0.999 3） for ammonium glycyrrhetate，2.38-950 ng/ml （r＝0.999 5） for ophiopogonin D，0.38-151 ng/ml （r＝0.999 7） for methylophiopogonanone A， and 0.43-171 ng/ml （r＝0.999 0） for methylophiopogonanone B； RSDs of precision， stability and reproducibility tests were no more than 3.0％；recoveries were  98.76％-107.60％（RSD＝1.7％）， 92.57％-105.80％（RSD＝2.9％），92.30％-103.10％（RSD＝2.1％），93.20％-108.10％（RSD＝3.0％），94.62％-99.20％（RSD＝1.2％），95.08％-104.80％（RSD＝2.6％），95.71％-104.80％（RSD＝1.9％），94.54％-105.50％（RSD＝2.3％） and 94.50％-103.00％（RSD＝1.6％），respectively（n＝6）. CONCLUSIONS：The method is rapid， simple， accurate and reliable， and suitable for 9 ingredients in Shasheng maidong decoction.