OBJECTIVE： To observe the effects of desogestrel combined with mifepristone on hormene level and endometrial thickness in patients with perimenopausal dysfunctional uterine bleeding （DUB） with no ovulation and to osberve hemostatic effect. METHODS： In retrospective study， 92 patients with the perimenopausal DUB  were divided into observation group （48 cases） and control group （44 cases）. Control group received symptomatic treatment such as hemostasis， anti-infective treatment， and Mifepristone tablet orally， 1 tablet erevy day， on pathological report diagnosis. A treatment course lasted for 30 d， and there were 3 courses of treatment in total. Observation group was additionally given Desogestrel tablet， 1 tablet erevy day， 21 d as a treatment course， received second course on the forth day of drug withdrawal hemorrhage， 3 courses in total. Hormone level and endometrial thickness before and after treatment， and hemostasis and the occurrence of ADR were compared between 2 groups. RESULTS： Compared with before treatment， serum level of progesterone and estrogen decreased in 2 groups significantly after treatment， with statistical significance （P＜0.05）； after treatment， serum level of FSH and LH， endometrial thickness in observation group were significantly lower than before treatment and control group， with statistical significance （P＜0.05）. Controlling bleeding time and complete hemostasis time of observation group were significantly shorter than those of control group， with statistical significance （P＜0.05）. The incidence of ADR in observation group was 8.33％， and that of control group was 13.64％， without statistical significance （P＞0.05）. CONCLUSIONS： Desogestrel combined with mifepristone is effective for perimenopausal DUB with no ovulation， can effectively reduce FSH and LH levels， and shorten hemostatic time with less ADR.