OBJECTIVE： To investigate the effects of calcitriol on related indicators in patients with chronic renal failure （CRF）. METHODS： 114 patients with CRF were randomly divided into observation group （57 cases） and control group （57 cases）. Control group was given high-quality low-protein and low phosphorus diet， if necessary， phosphate binders， Calcium D3 tablet and other conventional treatment； observation group was additionally given 0.25 μg Calcitriol soft capsule， once a day. The treatment course for both groups was 8 weeks. Serum levels of inflammatory factors， alkaline phosphatase， hemoglobin， erythrocyte， serum creatinine and urea nitrogen levels and adverse reactions in 2 groups before and after treatment were observed. RESULTS： Before treatment，there were no significant differences in the serum levels of inflammatory factors，alkaline phosphatase，hemoglobin，erythrocyte，senum creatininine and ureanitrogen between 2 groups（P＞0.05）. After treatment， serum inflammatory factors， alkaline phosphatase， serum creatinine and urea nitrogen levels in 2 groups were significantly shorter than before， and observation group was lower than control group， the differences were statistically significant （P＜0.05）； there were no significant differences in the hemoglobin and erythrocyte levels before and after treatment between 2 groups（P＞0.05）. And there was no obvious adverse reactions between 2 groups during treatment. CONCLUSIONS： Based on the conventional treatment， calcitriol can reduce the levels of serum inflammatory factors and improve micro-inflammatory state and renal function in patients with CRF.