OBJECTIVE： To analyze the blood concentration monitoring data of 4 commonly used antiepileptic drugs （AEDs，sodium phenytoin， carbamazepine， sodium valproic acid， oxcarbazepine） in order to provide reference for rational use of drugs in the clinic.  METHODS： 415 patients underwent 4 AEDs blood concentration monitoring were selected from our hospital during 2014-2015， and the results of blood concentration monitoring were analyzed statistically. RESULTS： There were 680 cases of AEDs blood concentration monitoring in total. The main objects of serum concentration monitoring were young and middle-aged（range from 19 to 60）， involving 449 cases in total （66.03％）. 360 cases were in the normal range（52.94％）. Among 361 patients receiving single drug therapy， the rates of serum concentration in the normal range were 80.77％ for carbamazepine， which was higher than other 3 AEDs （30.00％ for sodium phenytoin， 47.40％ for sodium valproic acid and 40.38％ for oxcarbazepine）， with statistical significance （P＜0.05）. Among 54 patients receiving combination therapy， the serum concentration monitoring data of 67.65％ patients treated with double-combination therapy and 100％ patients treated with triple-combination therapy deviated from normal range. CONCLUSIONS： The rate of AEDs blood concentration reaching the normal range are in low level in our hospital. It’s necessary to strengthen medication education for patients to improve the compliance of patients； clinical efficacy of AEDs is evaluated on the basis of blood concentration monitoring and clinical symptom， and combination therapy should be avoided as much as possible.