OBJECTIVE： To study the effects of Tanshinone capsules on glucose and lipid metabolism and serum sex hormone level in rats with polycystic ovary syndrome （PCOS）. METHODS： 90 female SD rats were randomly divided into normal group （distilled water）， model group （distilled water）， positive control group （metformin 200 mg/kg） and Tanshinone capsules low- dose， medium-dose and high-dose groups （30， 60， 90 mg/kg）， with 15 rats in each group. Those groups were induced PCOS model except for normal group； after modeling， those groups were given relevant medicine intragastrically for consecutive 28 d， once a day. The ovulation rate was compared before intervention and 28 d after intervention. Body weight， fat wet weight， fasting insulin （FINS）， fasting blood-glucose （FPG）， AUC of glucose， HOMA-IR， ISI， serum levels of FSH， LH and T were detected. RESULTS： Compared with normal group， anovulation， body weight， fat wet weight， FINS， FPG， AUC of glucose， HOMA-IR， FSH， LH and T were all increased significantly in model group， while ISI decreased significantly （P＜0.05）. Compared with model group， ovulation rate and ISI of positive control group and Tanshinone capsules groups were increased significantly after intervention， while body weight （except for Tanshinone capsules low-dose group）， fat wet weight （except for Tanshinone capsules low-dose group）， FINS， FPG， AUC of glucose， HOMA-IR， FSH， LH and T were all decreased significantly （P＜0.05）， especially in Tanshinone capsules high-dose group and positive control group. CONCLUSIONS： Tanshinone capsules can regulate glucose and lipid metabolism and serum sex hormone secretion disorder in PCOS rats.