OBJECTIVE： To establish a method for the residues determination of Pb， Cd， Cu， As and Hg in Codonopsis pilosula，and evaluate the quality evaluation of C. pilosula of Pingshun County in Shanxi province. METHODS： Microwave digestion-inductively coupled plasma mass spectrometry was adopted with KED scanning model， RF power was 1 550 W， sampling depth was 5.0 mm， plasma gas （argon） flow rate was 16.0 L/min， helium partial pressure was 0.1 mbar， argon gas was 0.6 mbar， the vacuum degree of 5×10－8 mbar， branch turbopump speed was 1 000 hz， sampling cone aperture was 1.0 mm， skimmer aperture was 0.5 mm， the spray chamber temperature was 2.7 ℃， the data collection was repeated 3 times. RESULTS： The linear range was 0-20 ng/ml for Pb （r＝0.999 3）， 0-10 ng/ml for Cd （r＝0.998 5）， 0-250 ng/ml for Cu （r＝0.998 8）， 0-20 ng/ml for As （r＝0.999 0） and 0-1.0 ng/ml for Hg（r＝0.997 9）； RSDs of precision， stability and reproducibility tests were lower than 3.0％； recoveries were 95.80％-100.20％ （RSD＝1.85％，n＝6）， 94.50％-98.00％ （RSD＝1.26％，n＝6）， 98.52％-102.43％ （RSD＝1.60％，n＝6）， 94.90％-98.70％（RSD＝2.29％，n＝6） and 96.00％-101.00％（RSD＝1.84％，n＝6）； the limits of detection were 0.021 0， 0.003 4， 0.043 7， 0.115 6 and 0.005 6 ng/kg， respectively. Pb， Cd， Cu， and As were detetcted，and Hg was not detected，the range of total contents was 7.185 2～12.558 0 mg/kg. CONCLUSIONS： The method is simple with good precision， stability and reproducibility， and can be used for the residues determination of Pb， Cd， Cu， As and Hg in C. pilosula； heavy metal residues in C. pilosula in Shanxi Pingshun county does not exceed limit values of national and industry standards