OBJECTIVE： To prepare fexofenadine hydrochloride sulfobutylether-β-cyclodextrin clathrate compound and its nasal thermosensitive hydrogels， and to evaluate its mucoadhesion. METHODS： Fexofenadine hydrochloride sulfobutylether-β-cyclodextrin clathrate compound was prepared by saturated aqueous system， and nasal thermosensitive hydrogels were prepared by cold method. Gel matrix and biological adhesive were screened by gelatinization temperature. Indigo carmine staining method was used to evaluate the retention time of prepared preparation and fexofenadine hydrochloride suspension in nasal cavity of rats. RESULTS： The clathrate was freely soluble in water. Inclusion rate of the clathrate was （86.0±2.7）％ （n＝3）. Gel matrix was 16％ poloxamer 407， biological adhesive was 0.5％ sodium hyaluronate. the retention time of prepared nasal thermosensitive hydrogels was 2.8 time as that of fexofenadine hydrochloride suspension. CONCLUSIONS： Fexofenadine hydrochloride sulfobutylether-β-cyclodextrin clathrate compound nasal thermosensitive hydrogels are prepared successfully and show good mucoadhesion.