OBJECTIVE： To investigate the maintenance effects of Lepidium meyenii powder on ovary of premature ovarian failure （POF） model rats with Kidney-Yang deficiency pattern. METHODS： 40 sexually mature rats （♀） were randomly divided to normal group， model group， epimedium group [positive drug， 1 g/（kg·d）]， L. meyenii powder low-dose and high-dose groups [2.5， 5 g/（kg·d）] with 8 rats in each group. Except for normal group， those groups were given hydrocortisone [32 mg/（kg·d）] intramuscularly every day， for consecutive 12 d to induce Kidney-Yang deficiency pattern POF model. After modeling， treatment groups were given relevant drugs intragastrically， and normal group and model group were given purified water intragastrically， twice a day， morning and afternoon， for consecutive 14 d. The changes of body weight， food consumption， ovary index， uterus index， estrous cycle and serum reproductive hormone （E2， FSH， LH） were observed in each group. RESULTS： At the end of administration， compared with normal group， body weight， ovary index and serum level of E2 decreased and estrous cycle disturbance was found in model group； while the levels of FSH and LH in serum， FSH/LH ratio increased （P＜0.05 or P＜0.01）. Compared with model group， estrous cycle disturbance， ovary index and serum reproductive hormone level were improved significantly in epimedium group and L. meyenii powder high-dose group （P＜0.05）. Only ovary index and serum level of LH were improved significantly in L. meyenii powder low-dose group （P＜0.05）， there was no statistical significance in other index （P＞0.05）. CONCLUSIONS： High-dose L. meyenii powder could promote the recovery of ovary function and the estrous cycle， and improve the ovary index and serum reproductive hormone level in POF model rats with Kidney-Yang deficiency pattern. It shows certain effect on the maintenance of ovarium.