OBJECTIVE： To observe the Hp eradication situation and safety of three kinds of drug regimen in the treatment of active chronic gastritis with helicobacter pykori （Hp） infection. METHODS： 150 active chronic gastritis patients with Hp infection were randomly divided into group A （50 cases）， group B （50 cases） and group C（50 cases）. Group A received Omeprazole enteric-coated capsule 20 mg， orally， twice a day+Amoxycillin capsules 1.0 g， orally， 3 times a day+Clarithromycin tablet 0.5 g， orally， once a day. Group B additionally received Colloidal bismuth pectin capsule 150 mg， orally， 3 times a day. Group C received Omeprazole enteric-coated capsule 20 mg， orally， twice a day+Amoxycillin capsules 1.0 g， orally， 3 times a day， 1-5 d， Omeprazole enteric-coated capsule 20 mg， orally， twice a day+ Clarithromycin tablets 0.5 g， orally， once a day+Metronidazole tablet 0.4 g， twice a day， 6-10 d. All patients treated for 10 d. Effective rate of pain relief， relief time of pain and gastrointestinal symptoms， Hp eradication rate， recurrence after 12 follow-up and the incidence of adverse reactions in all groups were observed. RESULTS： Effective rate of pain relief and Hp eradication rate in group C were higher than group B， followed by group A， relief time of pain and gastrointestinal symptoms， recurrence rate in group C were lower than group B， which was lower than group A， with significant differences （P＜0.05）. The incidence of adverse reactions in group C was lower than group A and group B， with significant differences （P＜0.05）； while there was no significant difference in group A and group B （P＞0.05）. CONCLUSIONS： Taking omeprazole in stages combined with antibiotics can effectively relieve abdominal pains， shorten disease course， improve Hp eradication rate， reduce long-term recurrence rate in the treatment of active chronic gastritis with Hp infection， with good safety.