暂无标题

ZHANG Junxia; LIN Hongjun; ZHANG Tingting; CHEN Wei; LI Zhenguo; ZHOU Jichun

您当前的位置：

首页 >

文章列表页 >

暂无标题

更新时间：2023-03-01

- 暂无标题
- China Pharmacy Vol. 27, Issue 34, (2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2016，
扫描看全文
ZHANG Junxia, LIN Hongjun, ZHANG Tingting, et al. [J]. China Pharmacy 27(34).(2016)
DOI：

ZHANG Junxia, LIN Hongjun, ZHANG Tingting, et al. [J]. China Pharmacy 27(34).(2016) DOI：

摘要

目的：研究益气活血风静胶囊对麻醉犬脑血流量（CBF）及脑血管阻力（CVR）的影响，为其临床应用提供药理学依据。方法：将18只Beagle犬随机分为假手术组（纯化水）、阳性对照中药组[脑心通胶囊，0.3 g（生药）/kg]、阳性对照化学药组（尼莫地平，7×10－3 g/kg）和益气活血风静胶囊高、中、低剂量组[2.52、1.26、0.63 g（生药）/kg）]，每组3只。犬麻醉后十二指肠给药，分别于给药前和给药30、60、120 min后测定血压、心率和CBF、CVR的变化。结果：给药30、60、120 min后，阳性对照中药组、阳性对照化学药组和益气活血风静胶囊高剂量组犬CBF明显增加，阳性对照化学药组和益气活血风静胶囊高剂量组犬CVR明显减小，阳性对照化学药组犬血压和心率降低，与假手术组比较差异均有统计学意义（P＜0.05或P＜0.01）。结论：益气活血风静胶囊可减小麻醉犬CVR、增加CBF，对血压及心率无影响。

Abstract

OBJECTIVE： To observe the effects of Yiqi huoxue fengjing capsules on the cerebral blood flow （CBF） and cerebral vascular resistance （CVR） in anesthetized dogs. METHODS： 18 Beagle dogs were randomly divided into sham operation group （purified water）， positive control TCM group [Naoxintong capsules， 0.3 g（crude drug）/kg]， positive control pharmaceutical chemicals group （nimodipine， 7×10－3 g/kg） and Yiqi huoxue fengjing capsules low-dose， medium-dose and high-dose groups [0.63， 1.26， 2.52 g（crude drug）/kg）]， with 3 dogs in each group. They were given relevant medicine via duodenum. CBF， CVR， blood pressure and heart rate of the dogs were measured before medication and 30， 60， 120 min after medication. RESULTS： 30， 60， 120 min after medication， CBF increased in positive control TCM group， positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsule high-dose group， while CVR decreased significantly in positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsules high-dose group， blood pressure and heart rate of positive control pharmaceutical chemicals group decreased， with statistical significance compared to sham operation group （P＜0.05 or P＜0.01）. CONCLUSIONS： Yiqi huoxue fengjing capsules can increase CBF and decrease CVR， and they have no effect on blood pressure and heart rate in anesthetized dogs.

关键词

益气活血风静胶囊脑血流量脑血管阻力Beagle犬

Keywords

Yiqi huoxue fengjing capsulesCerebral blood flowCerebral vascular resistanceBeagle dog

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

芳维甲酸乙酯在Beagle犬体内的药动学研究

美沙拉嗪缓释片单剂量与多剂量给药在Beagle犬体内的药动学研究

Related Author

YANG Hui

ZHOU Yuanda

HE Haixia

SUN Jihong

XIANG Rongfeng

YU Mingjie

XIONG Lirong

DAI Qing

Related Institution

No data

⁰

暂无标题

DOI：

摘要

Abstract

关键词

Keywords

references