OBJECTIVE： To observe the efficacy and safety of oxaliplatin， mitomycin and doxorubicin combined with three-dimensional conformal radiotherapy for patients with lack of blood supply hepatocellular carcinoma. METHODS：62 patients with lack of blood supply hepatocellular carcinoma who lose the opportunity of operation were randomly divided into control group （31 cases） and observation group （31 cases）. Control group received puncture through the femoral artery by Seldiner， selectively intervening in hepatic arteries for DSA angiography， then intravenously injected 130 mg/m2 Oxaliplatin for injection via the catheter， once every 2 weeks+Mitomycin for injection 10 mg， intravenously， once every 1-3 week（s）+Doxorubicin for injection 1.2 mg/kg， once every 3 weeks， then giving Iodinated oil emulsifier and Gelatin sponge particle for hepatic artery embolization， appropriate Iodinated oil emulsifier and Gelatin sponge particle once a month， for 3 times. Observation group was additionally received three-dimensional conformal radiotherapy 2 Gy， for 25-30 times with total dose of 50-60 Gy， once every 3 days. They were treated for 3-month. Clinical efficacy， the survival rate and median survival time after the first administration of drug for 1， 2 and 3 years in 2 groups were observed， and the incidence of adverse reactions was recorded. RESULTS： The total effective rate， the survival rate and median survival time in 1， 2 and 3 years in observation were significantly higher than control group， with statistical significance （P＜0.05）. The incidences of neutropenia， thrombocytopenia， hemoglobin decreased and radioactive disease in observation group were significantly higher than control group， with statistical significances （P＜0.05）. CONCLUSIONS： Oxaliplatin， mitomycin and doxorubicin combined with three-dimensional conformal radiotherapy have good efficacy for patients with hepatocellular lack of blood supply carcinoma， also can prolong the survival time， they show poor safety.