OBJECTIVE： To provide reference for standardized management of skin test of cephalosporin injection in our hospital. METHODS： In retrospective analysis， skin test of 8 kinds of cephalosporin [cefotaxime （1.0 g）， cefotaxime （0.5 g）， cefotiam （1.0 g）， cefotiam （0.5 g）， ceftazidime （0.5 g）， cefminox （0.5 g）， cefminox （1.0 g）， ceftriaxone （1.0 g）] and the cost of skin test， related cost of allergic reaction induced by cephalosporin injection were analyzed statistically during Sept. 1st， 2015-Aug. 31th， 2016. The cost of skin test of cephalosporin injection was compared with allergic reaction cost reduced by skin test. RESULTS： The positive rate of 100 330 patients who used above 8 kinds of cephalosporin injections was 6.27％； the rate of skin test was 82.49％； the direct cost of skin test was 3 434 411.72 yuan； the indirect cost was 141 985.12 yuan； the cost of patient was 3 162 901.44 yuan； the cost of medical insurance was 259 096.28 yuan； the cost of the whole society was 3 576 396.84 yuan. From the perspective of the whole society， the cost of skin test of cephalosporin injections was （447 049.61±247 395.07） yuan， and allergic reaction cost reduced by skin test was （316 075.48±260 600.49）yuan. The cost of skin test was significantly higher than allergic reaction cost reduced by skin test， with statistical significance （P＜0.05）. CONCLUSIONS： Skin test of cephalosporin injection is low in positive rate， has high expense. The government standardizes the management of skin test of cephalosporin injection and reduces the economic burden of patients under the premise of ensuring the safety of drug use.