OBJECTIVE： To establish a method for simultaneous determination of 6 residual organic solvents in aprepitant raw material as methanol， ethanol， acetone， isopropyl alcohol， methyl tert-butyl ether and tetrahydrofuran. METHODS： Headspace capillary gas chromatography was adopted. The determination was performed on DB-624 capillary column using temperature progra- mming. The temperature of injector port was 180 ℃， and flame ionization detector was used with temperature of 260 ℃. Nitrogen was used as carrier gas with flow rate 3.0 mL/min. The spilt ratio was 5 ∶ 1， and head-space injection volume was 1.0 mL. The head-space equilibrium temperature was set at 80 ℃， and equilibrium time was 40 min. RESULTS：The linear ranges of methanol， ethanol， acetone， isopropyl alcohol， methyl tert-butyl ether， tetrahydrofuran were 6.052-605.232 μg/mL（r＝0.999 9）， 9.987-998.718 μg/mL（r＝0.999 9）， 9.998-999.768 μg/mL（r＝0.999 8）， 9.986-998.634 μg/mL（r＝0.999 9）， 9.991-999.090 μg/mL（r＝0.999 7）， 1.461-146.133 μg/mL（r＝0.999 5）， respectively. The limits of quantitation were 1.782 1，2.079 0，0.749 8，1.777 8， 0.223 1，0.607 0 μg/mL； the limits of detection were 0.594 0，0.693 0，0.249 9，0.592 6，0.074 4， 0.202 3 μg/mL， respectively. RSD of precision test was lower than 2.0％. Only acetone and isopropyl alcohol were detected in stability test and reproducibility tests，RSD＜2.0％. Their recoveries were 99.34-100.75％（RSD＝0.52％，n＝9），98.20％-100.24％（RSD＝0.69％，n＝9）， 98.07％-100.07％（RSD＝0.84％，n＝9）， 99.86％-101.32％（RSD＝0.58％，n＝9），97.87％-104.02％（RSD＝2.13％，n＝9）， 98.26％-100.58％（RSD＝0.75％，n＝9）， respectively. CONCLUSIONS: The established method is simple， accurate and reproducible， and can be used for simultaneous determination of 6 residual organic solvents in aprepitant raw material.