OBJECTIVE： To investigate the role of clinical pharmacists in the anti-infection treatment for gas gangrene children. METHODS： Clinical pharmacists participated in the anti-infection treatment of a child with gas gangrene； according to clinical symptoms and consultation opinions of different departments， it was suggested to use Piperacillin sodium and tazobactam sodium for injection for initial anti-infection treatment. After debridement and drainage of left lower limb， removal of necrotic tissue， clinical pharmacists suggested to stop giving Piperacillin sodium and tazobactam sodium for injection and use Benzylpenicillin sodium for injection combined with Imipenem and cilastatin sodium for injection instead for anti-infection treatment according to etiological characteristic of gas gangrene and related guidelines. According to the results of bacterial culture of wound secretion and drug sensitivity test， clinical pharmacists additionally suggested to use Clindamycin hydrochloride and sodium chloride injection 0.6 g， q8 h， ivgtt to inhibit the generation of Clostridium perfringens. According to the changes of patient’s signs and etiological results， it was suggested to stop taking Clindamycin hydrochloride and sodium chloride injection， use Vancomycin hydrochloride for injection successively. RESULTS： The physicians adopted the suggestions of clinical pharmacists. After surgical treatment and anti-infection treatment， the patient’s condition was improved， the vital signs were stable， and the patient was transferred to the general ward of orthopedics department for further treatment. CONCLUSIONS： Clinical pharmacists participate in the treatment of gas gangrene child， and assist physicians to formulate and adjust anti-infection treatment plan according to related guidelines， clinical symptoms， etiological examination results and consultation opinions， so as to guarantee safe and effective drug use.