OBJECTIVE： To optimize the formulation technology of Ibuprofen sustained-release dropping pill and evaluate its in vitro drug-release characteristics. METHODS： Using stearic acid as sustained-release matrix， polyethylene glycol 6 000 as immediate-release matrix， melting method was used to prepare the Ibuprofen sustained-release dropping pill. Using the comprehensive scores of roundness， weight difference， drug loading rate， in vitro drug-release time as indexes， drug-matrix mass ratio， liquid temperature， condensation temperature， dropping distance as factors， orthogonal test was adopted to optimize the formulation technology， and verification test was conducted. In media of deionized water， hydrochloric acid solution （pH 1.2）， phosphate buffer （pH 4.5， 6.8）， the in vitro drug-release were compared between self-made sustained-release dropping pill and commercially available Ibuprofen sustained-release capsule， which were fitted for former drug-release behavior. RESULTS： The optimal formulation technology was as follows as mass ratio of ibuprofen-polyethylene glycol 6000-stearic acid of 4.0 ∶ 15.3 ∶ 0.7， liquid temperature of 83 ℃， condensation temperature of 8 ℃， and dropping distance of 11 cm. The weight difference of prepared 3 batches of Ibuprofen sustained-release dropping pill was 2.067％ （RSD＝1.19％）， roundness was 96.73％ （RSD＝0.28％）， drug loading rate was 96.31％ （RSD＝0.19％）， cumulative release rate in 12 h was 93.05％ （RSD＝0.81％）. The f2 values of self-made sustained-release dropping pill and commercially available Ibuprofen sustained-release capsule were greater than 50， the former one fitted more into Higucci equation （r＝0.988 1-0.997 2）. CONCLUSIONS： The formulation technology of Ibuprofen sustained-release dropping pill is successfully optimized， and in vitro drug-release behavior of prepared sustained-release dropping pill is similar to commercially available Ibuprofen sustained-release capsule.