OBJECTIVE： To observe the effects of Yishen huashi granules combined with Losartan potassium tablets on renal function indexes and inflammatory factors of patients with chronic glomerulonephritis. METHODS： A total of 107 patients with chronic glomerulonephritis in our hospital during Jan. 2015-Aug. 2016 were divided into observation group （53 cases） and control group （54 cases） according to therapy plan. Besides basic therapy， control group was given Losartan potassium tablets 50 mg， po，qd； observation group was additionally given Yishen huashi granules 10 g， po，tid， on the basis of control group. Both groups were treated for consecutive 2 mouths. Clinical efficacies， renal function indexes （Scr， BUN， 24 h urine protein quantification， urine red blood cell） and inflammatory factors （IL-13， CRP， TNF-α） levels were all observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： Clinical total response rate of observation group （86.79％） was significantly higher than that of control group （66.67％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in renal function indexes or inflammatory factors levels between 2 groups （P＞0.05）. After treatment， renal function indexes and inflammatory factors levels of 2 groups were significantly decreased； and observation group was significantly lower than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS：  Yishen huashi granules combined with Losartan potassium tablets in the treatment of chronic glomerulonephritis can improve renal function and reduce inflammation factor level with good safety.