OBJECTIVE： To compare the anti-inflammation， analgesia effects of decoctions extracted from Aconiti lateralis with different leaf shapes （dahua leaf， xiaohua leaf） from different producing areas （Jiangyou， Butuo）. METHODS： Animals were randomly divided into blank group （distilled water）， positive group， groups of Aconiti lateralis with dahua， xiaohua leaf from Jiangyou， groups of Aconiti lateralis with dahua， xiaohua leaf from Butuo （with dose of 5 g/kg， calculated by crude drug）. The anti-inflammation effect of decoctions extracted from Aconiti lateralis with different variety sources and leaf shapes was investigated by xylene-induced ear swelling test （n＝12） in mice and egg white-induced toe swelling test （n＝10） in rats （positive drug was Dexamethasone acetate tablet， 0.005 g/kg）. And its analgesic effect was investigated by acetic acid-induced writhing body reaction test （n＝12） and hot-plate-induced pain test （n＝12） in mice （positive drug was Morphine hydrochloride tablet， 0.002 5 g/kg）. RESULTS： The decoctions extracted from Aconiti lateralis with dahua， xiaohua leaf from Butuo and xiaohua leaf from Jiangyou can significantly reduce the ear swelling degree （P＜0.01）. The decoctions extracted from Aconiti lateralis with dahua leaf from Jiangyou and Butuo can significantly decrease the toe swelling degree after 6 h of medication （P＜0.05）. And decoctions extracted from Aconiti lateralis with xiaohua leaf from Butuo can significantly reduce the number of writhing body in mice with acetic acid-induced pain and prolong the pain threshold of mice with hot-plate-induced pain （P＜0.05 or P＜0.01）. CONCLUSIONS： Aconiti lateralis with dahua and xiaohua leaf from Butuo and with xiaohua leaf from Jiangyou show better anti-inflammation effect， and Aconiti lateralis with xiaohua leaf from Butuo shows better analgesic effect.