OBJECTIVE： To investigate protective effects of different doses of atorvastatin pretreatment on non-ST-segment elevation acute coronary syndrome （NSTE-ACS） patients underwent percutaneous coronary intervention （PCI）. METHODS： A total of 81 NSTE-ACS patients in a hospital during Jan. 2014-Apr. 2016 were divided into high-dose group （40 cases） and low dose group （41 cases） according to random number table. High-dose group was given Atorvastatin calcium tablet 80 mg 12-24 h before PCI， and then 40 mg 2 h before PCI. Low-dose group was given Atorvastatin calcium tablet 10 mg 12-24 h before PCI. Fractional flow reserve （FFR）， coronary flow reserve （CFR） and index of microcirculation resistance （IMR） after surgery were all observed in 2 groups. The levels of creatine kinase （CK）， creatine kinase myocardial band （CK-MB） and high sensitive C-reactive protein （hs-CRP） were compared between 2 groups before and after surgery. RESULTS： There was no statistical significance in FFR and CFR after surgery between 2 groups （P＞0.05）； IMR of high-dose group was significantly lower than low-dose group， with statistical significance （P＜0.05）. There was no statistical significance in CK， CK-MB or CRP between 2 groups before surgery （P＞0.05）. After surgery， the levels of CK-MB and CRP in low-dose group were significantly higher than high-dose group， with statistical significance （P＜0.05）. There was no statistical significance in CK level between 2 groups after surgery  （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： During PCI， pre-treatment with high-dose of atorvastatin （80→40 mg） could effectively improve microcirculatory disturbance and inhibit inflammatory reaction of NSTE-ACS patients.