OBJECTIVE： To improve the education quality of medical school， so as to provide the excellent human resources for the field of health. METHODS： 2011-2014 grades of students majoring in pharmaceutical administration， pharmacy （marketing direction） and other non-medical interdisciplinary subjects were selected from our school to complete the questionnaire which contained the questions about satisfaction and confidence for the major. The results of investigation were analyzed statistically. RESULTS： Totally 2 668 questionnaires were sent out， and 2 435 were recycled with effective recovery of 91.27％. Half of the students majoring in pharmaceutical administration or pharmacy （marketing） etc. were switched from other majors， and 38.40％ （935 number） of the students wanted to change the major. The major of clinical， nursing and anesthesiology were most preferred by the students. Only 15.52％ （378 number）， 26.32％ （641 number） of the students thought that the school paid enough attention to them or had a positive attitude to their major， respectively. Students majoring in pharmacy （marketing） and health services administration had the lowest satisfaction about their major and the attention paid by the school （P＜0.001）. With the growth of grade， the satisfaction of students in various aspects had declined （P＜0.001）. Only 44.72％ （1 089 number）， 34.25％ （834 number） of the students had positive attitude towards the study or were optimistic about the future， respectively. With the growth of the grade， students’ satisfaction in all aspects had declined （P＜0.001）. Compared to other students， freshman had more positive attitude towards the study or were more optimistic about the future （P＜0.001）. Besides， 33.65％ （491 number） of the students planning to work immediately after graduation lacked confidence to find a good job. CONCLUSIONS： The lower degree of satisfaction and confidence are found in the students majoring in non-medical interdisciplinary subject in the medical school， and this should be treated seriously by the school.