OBJECTIVE： To observe the effects of dexmedetomidine （Dex） on postoperative agitation of Wilson’s disease patients with secondary hypersplenism after genernl anesthesia of splenectomy. METHODS： A total of 60 Wilson’s disease patients with secondary hypersplenism underwent general anesthesia of splenectomy duning Jan.-Dec. 2016 were divided into control group and observation group according to random number table， with 30 cases in each group. Observation group was given intravenous pump of Dex 0.4 μg/kg at constant speed 15 min before anesthesia induction， and then maintained at 0.4 μg/（kg·h）till splenectomy completed. Control group was given constant volume of normal saline. Other anesthesia plans were same in 2 groups. Mean arterial pressure （MAP）， heart rate （HR） and pulse oxygen saturation （SpO2） of 2 groups were observed before pumping （T0）， before intubation （T1）， 1 min after intubation （T2）， before extubation （T3）， 3 min after extubation （T4）. Riker sedation-agitation score （SAS） were recorded in 2 groups at T3 and T4. The duration of stay in postanesthesia intensive care unit （PACU） and the occurrence of bradycardia were compared between 2 groups. RESULTS： At T0， there was no statistical significance in MAP， HR or SpO2 levels between 2 groups （P＞0.05）. At T1， T2， T3 and T4， MAP and HR levels of 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. SpO2 were 100％ at each time point， there was no statistical significance between 2 groups （P＞0.05）. Riker SAS scores of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. The incidence of bradycardia in observation group was 26.67％， which was significantly higher than 3.33％ of control group， with statistical significance （P＜0.05）. But this symptom was corrected after intravenous injection of atropine. The duration of stay in PACU in observation group was significantly shorter than control group， with statistical significance （P＜0.05）. CONCLUSIONS： Dex can keep postoperative hemodynamics stable in Wilson’s disease patients with secondary hypersplenism， reduce agitation and shorten the time of the patients transferring from PACU.