OBJECTIVE： To investigate the possible mechanism of Artemisia capillaries， and to provide reference for further development and utilization of it. METHODS： The effective components and related target protein of A. capillaries were screened by Traditional Chinese Medicine Systems Pharmacology （TCMSP） analysis platform database. The effective compound-target protein visual network of A. capillaries was established by using Cytoscape 3.5.1 software， topology analysis was also performed. The protein-protein interaction （PPI） network was constructed and analyzed by STRING database. KEGG pathway enrichment of target protein coding gene was analyzed by DAVID bioinformatics resource database. RESULTS： A total of 13 kinds of effective compounds， 189 target proteins and 34 enrichment pathways were selected. Quercetin， β-glutamol， isorhamnetin and artepillin C were main effective compounds. Prostaglandin G/H sythase 2（PTGS 2）， heat shock protein 90（HSP 90）， dipeptidyl peptidase Ⅳ， protein kinase A catalytic subunit Cα were main target proteins. Transcription factor AP-1 and cell tumor antigen p53 played a key role in PPI network. The target protein coding gene was rich in TNF-α signaling pathway， HIF-1 signaling pathway， Toll-like receptor signaling pathway， PI3K/Akt signaling pathway， T cell receptor signaling pathway， thyroid hormone signaling pathway， apoptotic signaling pathway， etc. CONCLUSIONS： Quercetin， β-glutamol and isorhamnetin of A. capillaries play an effect on PTGS2， HSP90， transcription factor AP-1 and other target proteins through TNF-α signaling pathway， HIF-1 signaling pathway and PI3K/Akt signaling pathway， so as to play anti-inflammatory and antitumor effect.