OBJECTIVE： To establish the method for simultaneous determination of 9 components in Huichun yuzi granules. METHODS： LC-MS/MS method was adopted. The determination was performed on Shim-pack XR-ODS C18 column with column temperature of 30 ℃. The sample size was 5 μL， and ion source as electrospray ion source； MRM mode was adopted. The acetonitrile-water was used as mobile phase for ferulic acid， rutin， paeonol， icariin and schisandrin （gradient elution）； positive ion mode monitoring was conducted. The methanol-0.1％ fomic acid water was used as mobile phase for naringin， verbascoside， amygdalin and protocatechuic acid （gradient elution）； negative ion mode monitoring was conducted. RESULTS： The linear ranges of ferulic acid， rutin， paeonol， icariin， schisandrin， naringin， verbascoside， amygdalin and protocatechuic acid were 0.499 5-500， 25-1 000， 0.245 9-250， 5.185 1-1 000， 0.981 9-1 000， 0.248 1-125， 2.510 4-250， 10-2 500， 4.999 7-1 000 ng/mL （r≥0.997 8）， respectively.  The limits of detection were 0.075， 0.30， 0.072， 0.015， 0.015， 0.075， 0.15， 0.30， 0.15 ng/mL，respectively； the limits of quantitation were 0.25， 1.00， 0.24， 0.51， 0.49， 0.25， 0.50， 0.99， 0.49 ng/mL， respectively. The recoveries rate were 91.39％-103.56％ （RSD＝1.03％-3.67％， n＝6）. RSDs of stability test ranged 1.4％-3.4％ （n＝6） within 48 h at room temperature.CONCLUSIONS： The method is rapid， sensitive and reproducible， and can be used for content determination of 9 components in Huichun yuzi granules. It can be used for quality control of Huichun yuzi granules.