OBJECTIVE： To study the effects of pre-hospital rescue measures on the prognosis of acute paraquat poisoning patients， confirm the feasibility of clay water suspension for pre-hospital rescue. METHODS： In retrospective controlled study， 15 patients with acute paraquat poisoning were selected from the First Affiliated Hospital of Guangxi Medical University during 2013-2015， and then divided into death group （n＝9） and survival group （n＝6） according to prognosis situation. The information of poisoning patients were collected， involving gender， age， paraquat intake， the time from patients taking paraquat to admission to hospital， pre-hospital resuce measures （drinking water to induce vomiting， oral clay water suspension to induce vomiting， finger spitting to induce vomiting）， blood concentration of paraquat within 30 min after admission. The index of paraquat poisoning severity （SIPP1＝blood concentration of paraquat at admission×interval between poisoning and admission；SIPP2＝paraquat intake×interval between poisoning and admission）were calculated and compared. RESULTS： Compared with death group， there was no statistical significance in gender， age， paraquat intake， interval between poisoning and admission or SIPP2 of survival group （P＞0.05）； the number of patients receiving pre-hospital rescue measure was higher （P＜0.05）； the blood concentration of paraquat and SIPP1 were lower significantly within 30 min after admission （P＜0.05）. Pre-hospital rescue measures of survival group included giving clay suspension solution orally to induce vomiting （3 cases）， drinking water to induce vomiting （one case） and scratching the throat with finger to induce vomiting （one case）. In death group， 2 patients drank water to induce vomiting before admission. CONCLUSIONS： Timely pre-hospital rescue measure can improve the prognosis effects of acute paraquat poisoning patients. Among pre-hospital rescue measure， it is a good method to give clay water suspension orally to induce vomiting.