OBJECTIVE： To decrease the price of anti-cancer drugs， and to alleviate economic burden and mental burden of cancer patients. METHODS： The effects of zero tariff of import anti-cancer drugs and drug price negotiation on main stakeholders were analyzed on the basis of stakeholder theory. The optimization suggestions were put forward from the perspective of stakeholders. RESULTS & CONCLUSIONS： There are certain influences for key stakeholders such as social security department， cancer patients， medical institutions， circulation enterprises of anti-cancer drugs and production enterprises of import anti-cancer drugs after implementing dual policy as zero tariff of anti-cancer drugs and drug price negotiation. There are difference in the interests， power， legitimacy， urgency and position of above stakeholders. It is suggested that the social security department speed up the inclusion of anticancer drugs into the medical insurance reimbursement list and alleviate patients’ burdens； cancer patients should increase the credibility for government and medical institutions and improve their health literacy； medical institutions establish “Internet＋” medical groups so as to make sure that cancer patients get information in time； circulation enterprises of anti-cancer drugs should open up e-commerce channels to avoid the middle price difference； production enterprises of import anti-cancer drugs encourage innovation research and development of new drugs. It realizes the ultimate and fundamental purpose of reducing the burden of cancer patients in all aspects， enhancing their rights and interests in health and medical services， and improving the availability of anti-cancer drugs for cancer patients.