OBJECTIVE： To investigate the effects of docetaxel combined with tiggio on the levels of carcinoembryonic antigen （CEA）， carbohydrate antigen 199 （CA199） and tumor associated material （TAM）， therapeutic efficacy in patients with advanced gastric cancer. METHODS： Totally 69 patients with advanced gastric cancer who were admitted to Yixing Tumor Hospital from Jan. 2016 to Aug. 2017 were divided into group A （35 cases） and group B （34 cases） according to treatment plan. Group A was given Docetaxel injection 75 mg/m2， once a week+Tiggio capsules， according to body surface area， twice a day， during first day-fourteenth day. Group B was given Cisplatin for injection 20 mg/m2， once a day， during first day-fifth day+Tiggio capsules（same dosage and usage as group A）. A treatment course lasted for 3 weeks of medication and 1 week of interval. Both groups were treated for consecutive 4 courses. The plasma levels of CEA， CA199 and TAM in 2 groups were observed before and after treatment. Clinical efficacies and the occurrence of ADR were recorded in 2 groups. RESULTS： Before treatment， there was no statistical significance in plasma levels of CEA， CA199 or TAM between 2 groups （P＞0.05）. After treatment， the levels of above indexes in 2 groups were decreased significantly， and group A was significantly lower than group B， with statistical significance （P＜0.05）. Total response rate of group A was 85.71％， which was significantly higher than 64.71％ of group B， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of Ⅰ-Ⅳ degree thrombocytopenia， anemia， neutropenia， liver damage， diarrhea or alopecia between 2 groups （P＞0.05）. CONCLUSIONS： Compared with cisplatin combined with tiggio therapy plan， the chemotherapy regimen of docetaxel combined with tiggio can reduce the levels of tumor markers as CEA， CA199 and TAM with satisfactory therapy efficacy， but cannot increase the occurrence of ADR.