OBJECTIVE： To provide feasible suggestions for the adjustment of medical cost control measure. METHODS： The drug proportion of outpatients and inpatients， drug cost per time （capita）， medical cost per time （capita） and increase rate of medical cost per time （capita） were analyzed in general hospitals of Jiangsu province during 2004-2016. The effects of drug proportion index cost control were analyzed in Jiangsu province， and special increase fields of medical cost was also analyzed. RESULTS & CONCLUSIONS： The drug proportion of outpatients and inpatients decreased from 55.40％， 47.84％ in 2004 to 43.18％， 36.24％ in 2016； drug cost per time （capita） increased from 75.89， 2 852.60 yuan in 2004 to 113.70， 4 421.74 yuan in 2016； medical cost per time （capita） increased from 136.98， 5 960.71 yuan in 2004 to 263.30， 12 203.00 yuan in 2016； increase rate of medical cost per time （capita） changed from 1.62％， 4.92％ in 2005 to 6.17％， 3.15％ in 2016. The effects of medical cost control measure were not satisfactory in general hospitals of Jiangsu province， and drug cost and medical cost increased continuously. The examination cost， medical cost and medical material cost accounted for a large proportion， which had a negative effect on the overall control effect of medical cost. The health administrative departments and policy-making departments should establish standard rational drug use mechanism and evaluation index system of structure rationalization， improve compensation mechanism of public medical institutions to solve the problem of rapid growth of medical cost.