OBJECTIVE： To establish simultaneous determination of 7 kinds of residual solvents in vorapaxar sulfate raw material. METHODS： The headspace gas chromatography was performed on Agilent DB-624 capillary column（programmed temperature） with inlet temperature of 220 ℃， detection temperature of 250 ℃ using nitrogen（99.999％） as carrier gas at the flow rate of 2.0 mL/min. The split ratio was 20 ∶ 1， and sample size was 1 mL. The headspace equilibrium temperature was 80 ℃，headspace equilibrium time was 30 min. RESULTS： The linear range of ethyl acetate， methanol， dichloromethane， ethanol， acetonitrile， tetrahydrofuran and toluene were 2.0-201.0 μg/mL（r＝0.999 8）， 1.2-122.3 μg/mL（r＝0.999 4）， 0.24-24.0 μg/mL（r＝0.999 2）， 2.0-200.3 μg/mL（r＝0.999 9）， 0.2-16.7 μg/mL（r＝0.999 9）， 0.3-29.0 μg/mL（r＝0.999 3）， 0.4-35.8 μg/mL（r＝0.999 3）， respectively. The limits of quantification were 2.0， 1.2， 0.24， 2.0， 0.2， 0.3， 0.4 μg/mL； the limits of detection were 0.60， 0.30， 0.07， 0.60， 0.06， 0.09， 0.12 μg/mL. RSDs of precision， stability and reproducibility tests were all lower than 4％. The recoveries were 97.02％-99.84％（RSD＝0.88％，n＝9）， 98.05％-99.64％（RSD＝0.54％，n＝9）， 97.37％-100.00％（RSD＝0.83％，n＝9）， 98.67％-99.60％（RSD＝0.34％，n＝9）， 97.56％-99.76％（RSD＝0.79％，n＝9）， 97.22％-99.45％（RSD＝0.65％，n＝9）， 97.75％-99.33％（RSD＝0.59％，n＝9）， respectively. RSDs of durability tests were all lower than 8％. Methanol， ethanol were detected in samples. CONCLUSIONS： The method is simple， accurate， precise， stable， reproducible and durable， and can be used for simultaneous determination of 7 kinds of residual solvents in vorapaxar sulfate raw material.