OBJECTIVE： To study the mechanism of Wendan decoction in the treatment of coronary heart disease based on network pharmacology. METHODS： Using oral bioavailability （OB） and drug like （DL） as reference， the active components of Wendan decoction， targets for treatment of coronary heart disease were screened and predicted by utilizing TCMSP， OMIM and Genecards database， DRAR-CPI. Cytoscape 3.6.0 software was adopted to construct an active component-coronary heart disease target network. The protein-protein interaction （PPI） network was established by using STRING database. Top 5 target proteins in the list of connectivity （the number of nodes passing through edges in PPI network） were screened. The activities of target protein with active components were predicted by molecular docking server. DAVID database was used to analyze metabolism pathway in target gene ontology （GO） biological process， Kyoto encyclopedia of genes and gnomes （KEGG）. RESULTS： A total of 147 active components and 143 targets related to coronary heart disease were screened， including albumin， apolipoprotein E， IL-6， TNF and C reactive protein， etc. After molecular docking analysis， the binding ability of active ingredients to target proteins was strong. Through GO and KEGG pathway enrichment analysis， active components participated in RNA polymerase Ⅱ promoter transcription regulation， cholesterol metabolism， hypoxia， drug reaction， inflammation and other biological processes， and regulated fat cell lipolysis pathway， cytokine-cytokine receptor interaction pathway， fat digestion and absorption pathway， peroxisome proliferator-activated receptor signaling pathway， renin-angiotensin pathway and so on. CONCLUSIONS： The active components of Wendan decoction play a role in the treatment of coronary heart disease through multiple targets and pathways. The results of this study provide a reference for further study of the pharmacological effect of Wendan decoction.