OBJECTIVE： To observe and compare the efficacy of Felodipine sustained-release tablets （Ⅱ） and Nifedipine sustained-release tablets for morning blood pressure surge control in peri-menopausal hypertension patients. METHODS： A total of 232 peri-menopausal hypertensive patients with morning blood pressure surge in our hospital from Jan. 2015 to May 2018 were randomly divided into observation group and control group. Observation group received Felodipine sustained-release tablet （Ⅱ） orally 5 mg/time， once every night. Control group received Nifedipine sustained-release tablet orally 20 mg/time， twice a day. The diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge were recorded in 2 groups after 1， 2， 3， 4 weeks of treatment. The therapeutic effects and ADR of 2 groups were compared after 4 weeks of treatment. RESULTS： There were 94 and 98 effective cases in observation group and control group after excluding the patients who didn’t obey the doctor’s advice or those who failed to follow up. Before treatment， there was no statistical significance in diastolic blood pressure， systolic blood pressure or the number of morning blood pressure surge between 2 groups （P＞0.05）. After one week of treatment， diastolic blood pressure of observation group was significantly lower than that of control group （P＜0.05）. After two weeks of treatment， the number of morning blood pressure surge of observation group was significantly lower than that of control group （P＜0.05）. After 3 weeks of treatment， diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge in observation group were significantly lower than control group （P＜0.05）. After 4 weeks of treatment， diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge in observation group were significantly lower than control group （P＜0.05）， and reached normal level. Total response rate of observation group （96.80％） was significantly higher than that of control group （84.69％） （P＜0.05）； the incidence of ADR in observation group （3.19％） was significantly control group （13.27％） （P＜0.05）. CONCLUSIONS： Felodipine sustained-release tablet shows excellent control effect on morning blood pressure surge in peri-menopausal hypertension patients， which provide reference for drug use in clinic.