OBJECTIVE: To improve and optimize the process of drug dispensing of inpatient pharmacy in our hospital. METHODS: According to the method of PDCA, the process of inpatient pharmacy drug dispensing in our hospital were investigated and analyzed in respects of situation, existing problems, measure formulation, intervention, evaluation and improvement. The data were collected by questionnaire survey and regular self-examination before (Mar.-May 2017) and after (Jun.-Aug. 2017) intervention. The existing problems in drug dispensing process of inpatient pharmacy were analyzed before intervention so as to propose improvement measures. The new process of drug dispensing and getting drug schedule were formulated; the training and publicity about getting drug rationally were further standardized, and the hospital information system was improved. After the implementation of intervention, the effects of intervention measures were evaluated and new problems were put forward using the average daily frequency and time of getting drug, satisfaction degree of clinical department as indexes; then the process of drug dispensing was improved continously. RESULTS: The main problems existing in the process of drug dispensing were high frequency and long-time of getting drug in the inpatient pharmacy of our hospital. After the implementation of intervention measures, the average daily frequency of getting medicine decreased from (57.7±6.2) times to (26.9±0.9) times, decreasing by 53.4%; the average daily time of getting medicine decreased from (1 041.6±91.6) min to (265.5±12.9) min, decreasing by 74.5%. The average daily frequency of getting drug, the average daily time of getting drug decreased significantly in each clinical department; there was statistical significance in above data, compared with before intervention (P<0.05 or P<0.01). CONCLUSIONS: PDCA cycle can improve inpatient pharmacy dispensing process and significantly reduce the frequency and time of getting drug. Also, it can improve work efficiency of pharmacy.