Objective To investigate the psychological status of patients with hyperthyroidism of different genders and the clinical effect of targeted care. Methods A total of 120 patients with hyperthyroidism admitted to our hospital from October 2018 to October 2020 were selected as the study subjects

who received targeted care. The symptom checklist 90（SCL-90） scale was used to investigate the psychological status of the patients at the early stage of admission and after one course of nursing intervention. The data were statistically analyzed. Results At the early stage of admission

the scores of paranoid

obsessive-compulsive

and hostile symptoms in male patients were significantly higher than those in female patients

while the scores of phobic symptoms were significantly lower than those in female patients（all P<0.05）. After the intervention

the scores of paranoid

obsessive-compulsive

phobic symptoms

anxiety

hostile

and depressive symptoms

and total SCL-90 scores in male patients were significantly lower than those before the intervention（all P<0.05）. The scores of obsessivecompulsive

phobic

anxiety

hostile

and depressive symptoms

somatization

and total SCL-90 scores in female patients were significantly lower than those before the intervention（all P<0.05）. Conclusion The psychological status of patients with hyperthyroidism of different genders remains diversified. It is necessary to take targeted care for these patients

which can effectively ameliorate their psychological status and improve therapeutic effects

with marked clinical value.