Experimental study on acute lung injury in animals caused by gas explosion in the closed tunnel

WENG Chang-mei; LI Guan-hua; GAN Hui-fang; ZHANG Dong-dong; ZHANG Liang-chao; KANG Jian-yi

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Experimental study on acute lung injury in animals caused by gas explosion in the closed tunnel

更新时间：2022-11-09

- Experimental study on acute lung injury in animals caused by gas explosion in the closed tunnel
- null Issue 10, Pages: 843(2022)
- 作者机构：
  
  陆军军医大学大坪医院武器杀伤生物效应评估研究室/创伤烧伤复合伤国家重点实验室,重庆,400042
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WENG Chang-mei, LI Guan-hua, GAN Hui-fang, et al. Experimental study on acute lung injury in animals caused by gas explosion in the closed tunnel. [J]. null (10):843(2022)
DOI：

WENG Chang-mei, LI Guan-hua, GAN Hui-fang, et al. Experimental study on acute lung injury in animals caused by gas explosion in the closed tunnel. [J]. null (10):843(2022) DOI：

摘要

目的通过在密闭巷道内引爆甲烷致伤动物，分析气体爆炸所致动物急性肺损伤的特点。方法在密闭的地下巷道试验系统内布放动物并引爆200 m3甲烷气体，用压力传感器及温度传感器置于各布放点测定冲击波及温度物理参数，测定伤前、伤后动物肺损伤标志物浓度，观察伤后动物肺组织病理学变化，并评估损伤程度。结果实验羊重度及中度肺损伤均占22.2%，兔极重度、重度、中度肺损伤均占12.5%；伤后48 h内羊和兔血清相关肺损伤标志物浓度显著高于伤前；肺损伤主要表现为肺出血、肺水肿、肺泡间隔断裂等。结论在可燃气体爆炸所致的早期急性肺损伤中，动物血清中相关肺损伤标志物浓度较伤前显著升高，能在一定程度上反映肺损伤严重程度，为气体爆炸所致急性肺损伤的特点研究及诊治提供参考依据。

Abstract

关键词

热冲复合伤急性肺损伤晚期糖基化终末产物受体表面活性蛋白A中性粒细胞弹性蛋白酶

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