Objective To investigate the clinical efficacy of the combination of Ginkgo biloba extract（GBE） and butylphthalide（NBP） in the treatment of cerebral ischemic stroke（CIS） and its effects on patients’ cerebral hemodynamics and neuron-specific enolase（NSE） and S100 calcium-binding protein β（S-100β） levels in serum. Methods Ninety-eight CIS patients admitted to a hospital in Yima from January 2018 to September 2019 were selected for the study and divided into control and study groups using a random number table

49 cases in each group. Patients in the control group were treated with NBP

and patients in the study group were treated with NBP combined with GBE injection. The clinical efficacy of patients in the 2 groups after 2 weeks of treatment was compared; the NIH Stroke Scale（NIHSS） scores

hemodynamic parameters in middle cerebral artery [mean flow velocity（MFV）

resistance index（RI）

pulsatility index（PI）]

inflammatory indices [interleukin-6（IL-6）

tumor necrosis factor α（TNF-α）

C-reactive protein（CRP）

pentraxin-3（PTX-3）]

laboratory indicators NSE

S-100β

activities of daily living（ADL） score and Barthel index before and after the treatment was compared between the two groups. Results At 2 weeks of treatment

the total treatment efficacy of patients in the study group and control group was 91.84% and 75.51%

respectively

with a statistically significant difference（P<0.05）. Before treatment

the differences were not statistically significant（P>0.05） when comparing the NIHSS scores of patients in the 2 groups; at 2 weeks of treatment

the NIHSS scores of patients in the 2 groups were lower than before treatment and lower in the study group than in the control group

with statistically significant differences（P<0.05）. Before treatment

the differences in MFV

PI and RI of the 2 groups were not statistically significant（P>0.05）; at 2 weeks of treatment

MFV of the 2 groups was higher than before treatment and higher in the study group than in the control group

with statistically significant differences（P <0.05）; at 2 weeks of treatment

PI and RI of the 2 groups were lower than before treatment and lower in the study group than in the control group

with statistically significant differences（P<0.05）. Before treatment

the differences in IL-6

TNF-α

CRP

PTX-3

NSE

and S-100β levels in the 2 groups were not statistically significant（P>0.05）; at 2 weeks of treatment

the levels of IL-6

TNF-α

CRP

PTX-3

NSE

and S-100β in the 2 groups were all lower than before treatment and lower in the study group than in the control group

with statistically significant differences（P <0.05）. Before treatment

there was no statistically significant difference between the ADL and Barthel index scores of the 2 groups（P>0.05）; at 2 weeks of treatment

the ADL and Barthel index scores of the 2 groups were higher than before treatment and higher in the study group than in the control group

with statistically significant differences（P<0.05）. Conclusion The combined treatment of CIS with GBE and NBP has obvious effects.It can significantly increase cerebral blood flow

reduce cerebrovascular resistance and pulsatility index

reduce inflammatory response

promote neurological recovery and improve daily living ability

thus having considerable application value.