Objective To explore the effects of hemoperfusion combined with hemofiltration in the treatment of patients with acute severe organophosphorus pesticide poisoning. Methods Eighty-two patients with acute severe organophosphorus pesticide poisoning admitted to a hospital in Jiyuan from May 2015 to May 2020 were selected and divided into a study group and a control group using the random number table method

with 41 cases in each group. Patients in the control group were given hemoperfusion treatment

and patients in the study group were given hemoperfusion-hemofiltration combination treatment. The success rate of resuscitation

treatment outcome

complications and changes of liver function before and after treatment were compared between the two groups. Results The resuscitation success rate of patients in the study group was 95.12%（39/41）

which was higher than that in the control group（80.49%

33/41）

and the difference was statistically significant（χ~2=4.100

P=0.043）. The duration of coma

recovery time of CHE activity and hospital stay were shorter in the study group than in the control group

and the differences were statistically significant（P<0.05）. the ALT and TBIL levels were lower in both groups after 72 h of treatment and lower in the study group than in the control group

with statistically significant differences（P<0.05）. The complication rate of patients in the study group was 5.13%

which was lower than that of 21.21% in the control group

but the difference was not statistically significant（χ~2=2.885

P=0.089）. Conclusion Hemoperfusion combined with hemofiltration can improve the success rate of resuscitation and treatment outcome

reduce liver function damage

and improve the prognosis of patients in the treatment of acute severe organophosphorus pesticide poisoning.