Objective To explore the effect of comprehensive care combined with comfort care in peptic ulcer bleeding. Methods Ninety-five patients with peptic ulcer bleeding admitted to a hospital in Nanyang from January 2018 to January 2020 were selected as study subjects and divided into study group（48 cases） and control group（47 cases） using the random number table method. The patients in the study group were given comprehensive care combined with comfort care intervention

and the patients in the control group were given conventional care intervention. The Hamilton Anxiety Rating Scale（HAMA）

Pittsburgh Sleep Quality Index（PSQI）

Subjective Comfort Evaluation Scale（SCES）

and Hamilton Depression Rating Scale（HAMD） scores were compared before and after 2 weeks of intervention

and the time to symptom relief was compared between the 2 groups of patients. Results The improvement time of abdominal pain

intestinal root obstruction

vomiting blood

and hunger pain symptoms was shorter in the study group than in the control group

and all differences were statistically significant（P<0.05）. Before the intervention

there was no statistically significant difference between the HAMA and HAMD scores of the 2 groups（P >0.05）; after the intervention

the HAMA and HAMD scores of the 2 groups were lower than before the intervention and lower in the study group than in the control group

with statistically significant differences（P<0.05）. Before the intervention

the differences in the PSQI and SCES scores of the 2 groups were not statistically significant（P>0.05）; after the intervention

the PSQI scores of the 2 groups were lower than before the intervention and lower in the study group than in the control group

with statistically significant differences（P<0.05）; the SCES scores of the 2 groups were higher than before the intervention and higher in the study group than in the control group

with statistically significant differences（P<0.05）. Conclusion Comprehensive care combined with comfort care can effectively reduce the negative emotions of patients with peptic ulcer bleeding

shorten the time of symptom relief

improve the quality of life and subjective comfort of patients

and can be promoted in clinical use.