Objective To investigate the effects of ultrasound-guided transversus abdominis plane block therapy on the pain

inflammatory factors and sleep quality of patients with abdominal post herpetic neuralgia. Methods One hundred and twenty-two patients with abdominal wall herpes zoster admitted to a hospital in Xinyang from April 2018 to April 2020 were selected as study subjects and divided into observation group and control group according to their treatment plans

61 cases each.Patients in the control group were treated with oral gabapentin

while patients in the observation group were treated with ultrasound-guided transversus abdominis plane block on the basis of the control group

and both groups received treatment for 4 weeks. The pain [visual analogue scale（VAS）]

sleep quality [Pittsburgh Sleep Quality Index（PSQI）]

inflammatory factors [tumor necrosis factor-α（TNF-α）

interleukin-6（IL-6）

interleukin-8（IL-8）]

immune function [immunoglobulin A（Ig A）

immunoglobulin G（Ig G）

immunoglobulin M（Ig M）] were compared between the groups

and the occurrence of complications was also compared between the groups. Results Before treatment

there was no statistically significant difference between the VAS and PSQI scores of the 2 groups（P>0.05）. At 7 d

1 month and 3 months after treatment

the VAS and PSQI scores of patients in the 2 groups were lower than those before treatment; at 1 month and 3 months after treatment

the VAS and PSQI scores of patients in the 2 groups were lower than those at 7 d after treatment; at 3 months after treatment

the VAS and PSQI scores of patients in the 2 groups were lower than those at 1 month after treatment

and the differences were all statistically significant（P<0.05）. When compared between groups

the VAS and PSQI scores of patients in the observation group were lower than those in the control group at 7 d after treatment

1 month after treatment and 3 months after treatment

and the differences were all statistically significant（P<0.05）. Before treatment

the TNF-α

IL-6 and IL-8 levels of patients in the 2 groups were compared

and the differences were not statistically significant（P >0.05）. After treatment

the levels of TNF-α

IL-6 and IL-8 in the 2 groups were lower than those before treatment and lower in the observation group than in the control group

with statistically significant differences（P<0.05）. Before treatment

the levels of Ig A

Ig G and Ig M in the 2 groups of patients were compared

and the differences were not statistically significant（P>0.05）. After treatment

the levels of Ig A

Ig G and Ig M in the 2 were lower than those before treatment and lower in the observation group than in the control group

with statistically significant differences（P<0.05）. The overall complication rate of patients in the observation group was 4.91%

which was lower than that of patients in the control group

19.67%

and the difference was statistically significant（χ2=6.157

P=0.013）. Conclusion Ultrasound-guided transversus abdominis plane block therapy can effectively relieve pain

improve sleep quality

improve immune function and inflammatory factor levels in patients with abdomen postherpetic neuralgia while also having a lower complication rate. Therefore

it is worth promoting in clinical use.