Objective To investigate the effects of etomidate combined with propofol in the induction of general anesthesia and its effects on the patients’ hemodynamics and red cell nature immune adhesion function（RNIAF）. Methods Ninety patients undergoing surgical treatment under general anesthesia with tracheal intubation in a hospital in Liaoning Province from October 2018 to October 2020 were selected and divided into a control group（50 patients） and an observation group（40 patients） using the random number table method. Patients in the control group were given propofol for induction of anesthesia

and the observation group were given etomidate combined with propofol for induction of anesthesia. The hemodynamic indexes [heart rate（HR）

systolic blood pressure（SBP）

diastolic blood pressure（DBP）

mean arterial pressure（MAP）]

intraoperative electroencephalographic bispectral index（BIS）

RNIAF index and postoperative quality indicators of awakening [awakening time

time to resume spontaneous breathing

blood oxygen saturation（Sp O2）] and the occurrence of postoperative adverse reactions were compared between the two groups before induction of anesthesia（T0）

at the time of intubation after induction（T1）

3 min after intubation（T2） and 10 min after intubation（T3）. Results The differences in HR

MAP

SBP and DBP levels at T1

T2 and T3 in the observation group were lower than those in the control group

and the differences were statistically significant（P <0.05）. There was no statistically significant difference between the BIS and RNIAF indices of the 2 groups at different time points（P>0.05）. There was no statistically significant difference between the postoperative awakening time

time to resume spontaneous breathing and Sp O2 level of the 2 groups（P>0.05）. There was no statistically significant difference between the incidence of adverse reactions of the 2 groups（P>0.05）.Conclusion Etomidate combined with propofol for induction of anesthesia can help maintain the hemodynamic balance during anesthesia and protect the RNIAF of patients

and it has relatively low impact on the quality of postoperative awakening and has a high safety.