Objective To explore the clinical study of diversified nursing combined with psychological intervention for patients undergoing colon cancer resection.Methods A total of 206 patients who underwent colon cancer resection in a hospital in Nanyang from April 2018 to December 2020 were selected as study subjects and divided into study and control groups using the random number table method

103 cases each.The patients in the control group were given diversified care and the patients in the study group were given psychological care intervention on the basis of the control group

and the patients in the two groups were cared for 30 d.The changes in gastrointestinal function

psychological status [self-rating anxiety scale（SAS）

self-rating depression scale（SDS）] and quality of life（QOL） scores of the patients in the two groups were compared before and after care.Results After care

the first exhaust time

time to recovery of bowel movements

and time to removal of gastric tube were significantly shorter in the study group than in the control group（P<0.001）.Before care

there was no statistically significant difference in SAS and SDS scores between the 2 groups of patients（P>0.05）.After care

the SAS and SDS scores of patients in the 2 groups were lower than before care

and the study group was lower than the control group

and the differences were statistically significant（P<0.001）.Before care

there was no statistically significant difference between the QOL scores of patients in the 2 groups（P>0.05）.After care

the QOL scores of the patients in both groups were lower than before care

and the study group was lower than the control group

and the differences were statistically significant（P <0.05）.Conclusion Diversified nursing combined with psychological intervention can significantly improve the anxiety and depression of colon cancer resection patients

and effectively improve the gastrointestinal function and quality of life of patients.It has considerable clinical value and is worth promoting.