Effect of trimetazidine combined with levocanidine on the hear function of patients with ischemic cardiomyopathy with heart failure

Han Yongjian; Yang Lili

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Effect of trimetazidine combined with levocanidine on the hear function of patients with ischemic cardiomyopathy with heart failure

更新时间：2022-11-04

- Effect of trimetazidine combined with levocanidine on the hear function of patients with ischemic cardiomyopathy with heart failure
- Health Medicine Research and Practice Vol. 19, Issue 1, Pages: 49-51(2022)
- 作者机构：
  
  南阳医学高等专科学校第一附属医院心血管内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.6;R542.2
- Published：2022，
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Han Yongjian, Yang Lili. Effect of trimetazidine combined with levocanidine on the hear function of patients with ischemic cardiomyopathy with heart failure. [J]. Health Medicine Research and Practice 19(1):49-51(2022)
DOI：

Han Yongjian, Yang Lili. Effect of trimetazidine combined with levocanidine on the hear function of patients with ischemic cardiomyopathy with heart failure. [J]. Health Medicine Research and Practice 19(1):49-51(2022) DOI：

摘要

目的探讨曲美他嗪联合左卡尼汀对缺血性心肌病伴心力衰竭患者心功能的影响。方法选取2017年5月—2020年5月南阳市某医院心内科收治的86例缺血性心肌病伴心力衰竭患者为研究对象

根据不同的治疗方式分为对照组（43例）和观察组（43例）。对照组患者予以左卡尼汀治疗

观察组患者予以曲美他嗪联合左卡尼汀治疗

2组患者均持续治疗3个月。比较2组患者临床疗效和治疗前后的心输出量（CO）、每搏输出量（SV）及左室射血分数（LVEF）

QT离散度（QTd）、校正QT离散度（QTcd）及QRS。结果对照组患者治疗总有效率为83.72%

低于观察组的97.67%

差异有统计学意义（χ

=5.075

P=0.024）。治疗前

2组患者心功能各项指标比较

差异均无统计学意义（P

0.05）。治疗后

观察组患者CO、SV及LVEF高于治疗前

且高于对照组

差异均有统计学意义（P

0.05）;QTd、QTcd及QRS均低于治疗前

且低于对照组

差异均有统计学意义（P

0.05）。结论曲美他嗪联合左卡尼汀对缺血性心肌病伴心力衰竭患者心功能改善明显

值得临床推广使用。

Abstract

Objective To investigate the effect of trimetazidine combined with levocanidine on the heart function of patients with ischemic cardiomyopathy with heart failure.Methods Eighty-six patients with ischemic cardiomyopathy with heart failure admitted to the cardiology department of a hospital in Nanyang from May 2017 to May 2020 were selected for the study and divided into a control group（43 cases） and an observation group（43 cases） according to different treatment modalities.The control group was treated with levocanidine

and the observation group was treated with trimetazidine combined with levocanidine

and both groups were treated for 3 months.The clinical efficacy

cardiac output（CO）

stroke volume（SV） and left ventricular ejection fraction（LVEF）

QT dispersion（QTd）

corrected QT dispersion（QTcd） and QRS of the patients in the two groups were compared before and after treatment.Results The total effective rate of treatment for patients in the control group was 83.72%

which was lower than 97.67% in the observation group

and the difference was statistically significant（χ~2= 5.075

P= 0.024）.Before treatment

there was no statistically significant difference between the indices of heart function in the 2 groups of patients（P>0.05）.After treatment

SV and LVEF of patients in the observation group were higher than those before treatment and significantly higher than those in the control group

and the differences were all statistically significant（P<0.05）;QTd

QTcd and QRS were all lower than before treatment and significantly lower in the observation group than in the control group

and the differences were all statistically significant（P<0.05）.Conclusion The improvement of heart function in patients with ischemic cardiomyopathy with heart failure by trimetazidine combined with levocanidine is obvious

and the therapy is worthy of clinical promotion.

关键词

曲美他嗪左卡尼汀缺血性心肌病心力衰竭心功能

Keywords

TrimetazidineLevocarnitineIschemic cardiomyopathyheart failureHeart function

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