Lung cancer is one of the common clinical malignant tumors with high malignancy and poor prognosis.Non-small cell lung cancer（NSCLC） is the most common histological type of lung cancer

accounting for about85% of all lung cancers.Because of its insidious onset

some patients with NSCLC are diagnosed with advanced lung cancer at the first diagnosis.Treatment is based on systemic therapy such as targeted therapy

immunotherapy and platinum-containing two-drug chemotherapy.Patients in good health can still benefit from third-line therapy after the morestandard first-and.second-line treatments.The efficacy of third-line therapy is poor after failure of second-line therapy

and there is clinical variation in the treatment of patients;a completely uniform and effective third-line treatment regimen has not yet been reached.This article reviews the research progress of treatment options for advanced NSCLC in recent years and proposes a third-line treatment option.