Effects of serum NT-proBNP and Galectin-3 levels on the prognosis of patients with acute ischemic stroke

Han Li; Feng Fang; Jin Ge; Nie Beibei

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Effects of serum NT-proBNP and Galectin-3 levels on the prognosis of patients with acute ischemic stroke

更新时间：2022-11-04

- Effects of serum NT-proBNP and Galectin-3 levels on the prognosis of patients with acute ischemic stroke
- Health Medicine Research and Practice Vol. 18, Issue 4, Pages: 65-69(2021)
- 作者机构：
  
  郑州大学第一附属医院神经内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2021，
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Han Li, Feng Fang, Jin Ge, et al. Effects of serum NT-proBNP and Galectin-3 levels on the prognosis of patients with acute ischemic stroke. [J]. Health Medicine Research and Practice 18(4):65-69(2021)
DOI：

Han Li, Feng Fang, Jin Ge, et al. Effects of serum NT-proBNP and Galectin-3 levels on the prognosis of patients with acute ischemic stroke. [J]. Health Medicine Research and Practice 18(4):65-69(2021) DOI：

摘要

目的探讨血清N末端脑钠肽前体(NT-proBNP)和半乳糖凝集素-3(Galectin-3)水平对急性缺血性脑卒中(AIS)患者预后的影响。方法选取2018年2月-2019年4月郑州市某医院诊治的76例AIS患者为研究对象

按病情程度分为2个亚组(轻度组与重度组)

并取同期76例体检健康者作为对照组。比较3组研究对象的血清NT-proBNP和Galectin-3水平。按照患者的改良Rankin(m RS)评分将患者分为预后良好组与预后不良组

比较2组患者血清NT-proBNP和Galectin-3水平

并分析其与患者预后的相关性。结果重度组NT-proBNP和Galectin-3水平明显高于轻度组与对照组

轻度组明显高于对照组

差异均有统计学意义(P<0.05)。预后良好组患者NT-proBNP和Galectin-3水平明显低于预后不良组

差异均有统计学意义(P<0.05)。经相关性分析发现

AIS患者NT-proBNP和Galectin-3水平与m RS评分呈正相关(r=0.892、0.987;P<0.05)。结论病情越重、预后越差AIS患者的NT-proBNP、Galectin-3水平越高

联合这2项指标的检测能为AIS的临床诊治及预后评估提供参考。

Abstract

Objective To investigate the effects of serum N-terminal pro-brain natriuretic peptide（NT-pro BNP） and galactose lectin-3（Galectin-3） levels on the prognosis of patients with acute ischemic stroke（AIS）.Methods Seventy-six patients with AIS who were treated in a hospital in Zhengzhou from February 2018 to April 2019 were selected for the study and divided into 2 subgroups（mild and severe groups） according to the degree of disease

and 76 physically healthy individuals were taken as the control group during the same period.Serum NT-pro BNP and Galectin-3 levels were compared between the 3 study groups.Patients were divided into good prog-nosis group and poor prognosis group according to their modified Rankin scores（m RS）.Serum NT-pro BNP and Galectin-3 levels were compared between the 2 groups

and their correlation with patient prognosis was analyzed.Results The NT-pro BNP and Galectin-3 levels in the severe group were significantly higher than those in the mild group and the control group

and those in the mild group were significantly higher than those in the control group

and the differences were statistically significant（P<0.05）.The NT-pro BNP and Galectin-3 levels were significantly lower in patients in the good prognosis group than in the poor prognosis group

and the differences were all statistically significant（P <0.05）.The correlation analysis revealed that NT-pro BNP and Galectin-3 levels in patients with AIS were positively correlated with m RS scores（r=0.892

0.987;P<0.05）.Conclusion The more severe the disease and the worse the prognosis

the higher the levels of NT-pro BNP and Galectin-3 in AIS patients

and the combined testing of these two indicators can provide a reference for clinical diagnosis and treatment and prognosis assessment of AIS.

关键词

缺血性脑卒中N末端脑钠肽前体半乳糖凝集素-3预后

Keywords

Ischemic strokeN-terminal pro-brain natriuretic peptideGalactose-3Prognosis

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