Effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure

Jia Jiancheng; Sun Donghui; Xia Dongxue; Wang Yanbin

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Effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure

更新时间：2022-11-04

- Effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure
- Health Medicine Research and Practice Vol. 18, Issue 3, Pages: 73-75(2021)
- 作者机构：
  
  驻马店市第一人民医院重症医学科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.6;R563.1
- Published：2021，
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Jia Jiancheng, Sun Donghui, Xia Dongxue, et al. Effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure. [J]. Health Medicine Research and Practice 18(3):73-75(2021)
DOI：

Jia Jiancheng, Sun Donghui, Xia Dongxue, et al. Effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure. [J]. Health Medicine Research and Practice 18(3):73-75(2021) DOI：

摘要

目的探讨纳洛酮联合注射用甲泼尼龙琥珀酸钠治疗重症肺炎合并心力衰竭的临床效果。方法选取2018年3月-2020年3月河南省某医院收治的78例重症肺炎合并心力衰竭患者为研究对象

采用随机数字表法分为对照组与观察组

每组39例。2组均给予常规治疗

对照组患者给予注射用甲泼尼龙琥珀酸钠治疗

观察组患者在对照组基础上联用纳洛酮治疗

比较2组患者疗效、各项症状及体征持续时间、心功能改善情况及血气指标变化情况。结果观察组患者治疗总有效率为94.87%

高于对照组的71.79%

差异有统计学意义（χ

=7.477

0.05）。2组患者治疗后左室射血分数（LVEF）大于治疗前且观察组大于对照组

而2组患者左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）小于治疗前且观察组小于对照组

差异均有统计学意义（P

0.05）。2组患者治疗后动脉血氧分压（PaO

）、氧合指数（PaO

/FiO

）高于治疗前且观察组高于对照组

而动脉二氧化碳分压（PaCO

）低于治疗前且观察组低于对照组

差异均有统计学意义（P

0.05）。结论纳洛酮联合注射用甲泼尼龙琥珀酸钠治疗重症肺炎合并心力衰竭疗效较好

有助于改善患者心功能及血气指标

改善患者预后。

Abstract

Objective To explore the clinical effect of naloxone combined with injectable methylprednisolone sodium succinate in the treatment of severe pneumonia combined with heart failure.Methods Seventy-eight patients with severe pneumonia combined with heart failure admitted to a hospital in Henan Province from March 2018 to March 2020 were selected as study subjects and divided into control group and observation group using a random number table method

39 cases in each group.Both groups were given conventional treatment.Patients in the control group were treated with injectable methylprednisolone sodium succinate

and patients in the observation group were treated with naloxone combined with injectable methylprednisolone sodium.The efficacy

duration of symptoms and signs

improvement in cardiac function

and changes in blood gas indexes were compared between the 2 groups.Results The total effective rate of treatment for patients in the observation group was 94.87 %

which was higher than that of the control group（71.79%）

and the difference was statistically significant（χ

=7.477

0.05）.LVEF was higher after treatment in both groups

and it was higher in the observation group than in the control group.LVESD and LVEDD were lower after treatment in both groups

and they were lower in the observation group than in the control group.All differences were statistically significant（P

0.05）.PaO

and PaO

/FiO

were higher in both groups after treatment

and they were higher in the observation group than in the control group.PaCO

was lower in both groups after treatment

and it was lower in the observation group than in the control group.All differences were statistically significant（P

0.05）.Conclusion Naloxone combined with injectable methylprednisolone sodium succinate is effective in the treatment of severe pneumonia combined with heart failure

as it helps to improve patients’ cardiac function and blood gas index and improve their prognosis.

关键词

纳洛酮注射用甲泼尼龙琥珀酸钠重症肺炎心力衰竭肺炎疗效

Keywords

NaloxoneInjectable sodium methylprednisolone succinateSevere pneumoniaheart failurePneumoniaEfficacy

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