Clinical Analysis of Acute Post-Streptococcal Nephritis in Children with Massive Proteinuria

Li Zhihui; Xiong Bingyao; Kang Zhijuan; Wu Tianhui; Xun Mai

您当前的位置：

首页 >

文章列表页 >

Clinical Analysis of Acute Post-Streptococcal Nephritis in Children with Massive Proteinuria

更新时间：2022-11-04

- Clinical Analysis of Acute Post-Streptococcal Nephritis in Children with Massive Proteinuria
- Vol. 28, Issue 8, Pages: 39-43(2022)
- 作者机构：
  
  南华大学儿科学院，湖南省儿童医院,湖南,长沙,410007
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2022，
扫描看全文
Li Zhihui, Xiong Bingyao, Kang Zhijuan, et al. Clinical Analysis of Acute Post-Streptococcal Nephritis in Children with Massive Proteinuria. [J]. 28(8):39-43(2022)
DOI：

Li Zhihui, Xiong Bingyao, Kang Zhijuan, et al. Clinical Analysis of Acute Post-Streptococcal Nephritis in Children with Massive Proteinuria. [J]. 28(8):39-43(2022) DOI：

摘要

目的：探讨大量蛋白尿表现的儿童急性链球菌感染后肾炎（APSGN）病情迁延的危险因素，为儿童慢性肾脏病防治提供参考。方法：收集2007年2月至2018年12月在我院肾内科住院的具有大量蛋白尿表现的APSGN患儿资料，根据蛋白尿持续时间是否<3个月分为Ⅰ组和Ⅱ组，分析两组临床及病理因素的差异，并采用Logistic回归分析蛋白尿持续时间延长的危险因素。结果：收集患儿119例，其中男84例，女35例，年龄（9.39±2.80）岁。两组高血压、急性肾损伤、肾脏C1q沉积发生率及血C4水平比较，差异有统计学意义（P<0.05）；Logistic回归分析显示，高血压、低水平血C4是蛋白尿持续时间延长的危险因素（P<0.05）。结论：高血压、低水平血C4是大量蛋白尿表现的APSGN患儿病情迁延的危险因素，需警惕发展为慢性肾脏病。

Abstract

Objective: To explore the risk factors of acute post-streptococcal nephritis (APSGN) in children with massive proteinuria

so as to provide reference for the prevention and treatment of chronic kidney disease in children. Methods: Data of APSGN children with massive proteinuria admitted into the nephrology department of Hunan Children’s Hospital from Feb. 2007 to Dec. 2018 were extracted

and all patients were divided into the group Ⅰ and group Ⅱ according to whether the duration of proteinuria was less than 3 months. Differences of clinical and pathological factors between two groups were analyzed

and risk factors of prolonged duration of proteinuria were analyzed by Logistic regression. Results: A total of 119 children were enrolled

including 84 males and 35 females

aged (9.39±2.80) years old. There were statistically significant differences in the incidence of hypertension

acute kidney injury

renal C1q deposition and blood C4 level between two groups (P<0.05). Logistic regression analysis showed that hypertension and low blood C4 level were risk factors for prolonged duration of proteinuria (P<0.05). Conclusion: Hypertension

low blood C4 level are risk factors for the progression of APSGN in children with massive proteinuria

which should be vigilant for the development of chronic kidney disease.

关键词

急性肾小球肾炎链球菌感染儿童大量蛋白尿蛋白尿持续时间

Keywords

acute glomerulonephritisstreptococcal infectionchildrenmassive proteinuriauration of proteinuria

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of 36 Cases of Drug Poisoning in Children in a Grade III, Level A General Hospital andConsideration on Pharmaceutical Care

Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Sirolimus in the Treatment of 5 Cases of Blue Rubber Bleb Nevus Syndrome in Children and Literature Review

Systematic Review on Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metabolic Disordersin Children

Drug Utilization Evaluation of Voriconazole for Injection in Children Based on Weighted Technique for Order Preference by Similarity to Ideal Solution Method

Related Author

Wang Peng

Xu Ying

Zhang Xiaoming

Zhang Shaonan

Li Changsong

Li Yunxiang

Li Xiaojing

Sun Canlin

Related Institution

The Second People’ s Hospital of Anhui Wuhu, Anhui Wuhu

Jiangsu Taizhou People’s Hospital, Jiangsu Taizhou

Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou Key Laboratory of Children’s Digestive Diseases

Kunming Children’s Hospital / Children’s Hospital of Kunming Medical University, Kunming

Kunming MedicalUniversity, Kunming

⁰